1. 国家自然基金委,国家自然科学基金面上项目:FGF21介导有氧运动改善衰老心肌易损性的作用及机制研究,82272601,2024.01-2026.12,主持(第一位),52万元,在研。
2. 山东省重点人才工程(泰山学者)项目:心肌毒性的康复机制和康复策略,No.TSQN202306013,2023.07-2026.06,主持(第一位),75万元,在研。
3. 省科技厅,省自然科学基金面上项目:P53-TRB3信号通路在SFN改善心肌胰岛素抵抗治疗糖尿病心肌病的作用和机制研究,ZR2021MH330,2022.01-2024.12,主持(第一位),10万元,在研。
4. 必赢国际bwi437,齐鲁青年学者项目:糖尿病心肌病的康复机制和康复策略,No.SD21330089963007, 主持(第一位),100万元,结题。
5. 国家自然基金委,国家自然科学基金青年项目:成纤维细胞生长因子 21 通过抑制 p53 活性对糖尿病心肌病保护作用的研究,8160063,2017.01-2019.12,主持(第一位),17万元,结题。
1、必赢国际bwi437,校级项目:《临床护理研究思路与方法》课程思政建设【研·思政】,2024-2026年,第二位,在研
2、必赢国际bwi437,校级项目:《临床护理研究思路与方法》优质课程建设,2024-2026年,第二位,在研
3、必赢国际bwi437,校级项目:智慧线上线下混合教学模式在临床护理研究思路与方法中的应用,2021-2023年,第二位,结题
4、必赢国际bwi437齐鲁医学院,校级项目:临床护理研究思路与方法数字化课程建设,2019-2021年,第二位,结题
5、山东省教育厅,省级项目:临床护理研究思路与方法案例库建设,2019年,第二位,5万,结题
(1)Ting Gao, Yufeng Tang, Tao Zeng, Jie Wang, Xiaohui Zhang, Qingbo Liu, Xun Guan, Xinyu Tang, Guangping Lu, Jiahao Li, Mingrui Liu, Dongmei Zhang, Sixuan Lv, Junlian Gu*. Neuraminidase 1 Exacerbated Glycolytic Dysregulation and Cardiotoxicity by Destabilizing SIRT1 through Interactions with NRF2 and HIF1α. Advanced Science. 2025.(中科院1区,Top期刊,发表当年5-Year IF=16.3;独立通讯作者)
(2)Yuanfang Guo, Jie Wang, Dongmei Zhang, Yufeng Tang, Quanli Cheng, Jiahao Li, Ting Gao, Xiaohui Zhang, Guangping Lu, Mingrui Liu, Xun Guan, Xinyu Tang, Junlian Gu*. Diabetes-associated sleep fragmentation impairs liver and heart function via SIRT1-dependent epigenetic modulation of NADPH oxidase 4. Acta Pharmaceutica Sinica B. Available online 2025 Jan 2.(中科院1区,Top期刊,发表当年IF=14.7;独立通讯作者)
(3)Jie Wang, Ting Gao, Dongmei Zhang, Yufeng Tang, Junlian Gu*. Phospholipase C epsilon 1 as a therapeutic target in cardiovascular diseases. Journal of Advanced Research. 2025 Jan 22:S2090-1232(25)00051-7.(中科院1区,Top期刊,发表当年IF=11.3997;独立通讯作者)
(4)Guangping Lu, Yufeng Tang, Ou Chen, Yuanfang Guo, Mengjie Xiao, Jie Wang, Qingbo Liu, Jiahao Li, Ting Gao, Xiaohui Zhang, Jingjing Zhang, Quanli Cheng, Rong Kuang, Junlian Gu*. Aberrant activation of p53-TRIB3 axis contributes to diabetic myocardial insulin resistance and sulforaphane protection. Journal of Advanced Research. 2024 Jul 26:S2090-1232(24)00307-2. (中科院1区,Top期刊,发表当年IF=11.3997;共同通讯作者)
(5)Jiahao Li, Yufeng Tang, Guangping Lu, Qingbo Liu, Yuanfang Guo, Jie Wang, Mengjie Xiao, Ting Gao, Xiaohui Zhang, Junlian Gu*. Elevation of p53 sensitizes obese kidney to adriamycin-induced aberrant lipid homeostasis via repressing HNF4α-mediated FGF21 sensitivity. Journal of Advanced Research. 2024 Jul 15:S2090-1232(24)00299-6.(中科院1区,Top期刊,发表当年IF=11.3997;独立通讯作者)
(6)Mengjie Xiao, Yufeng Tang, Jie Wang (a) , Guangping Lu, Jianlou Niu, Jie Wang (b), Jiahao Li, Qingbo Liu, Zhaoyun Wang, Zhifeng Huang, Yuanfang Guo, Ting Gao, Xiaohui Zhang, Shouwei Yue, Junlian Gu*. A new FGF1 variant protects against adriamycin-induced cardiotoxicity via modulating p53 activity. Redox Biology. 2022 Feb:49:102219.(中科院1区,Top期刊,发表当年5-Year IF=12.038;独立通讯作者)
(7)Jie Wang A, Yufeng Tang, Jingjing Zhang, Jie Wang B, Mengjie Xiao, Guangping Lu, Jiahao Li, Qingbo Liu, Yuanfang Guo, Junlian Gu*. Cardiac SIRT1 ameliorates doxorubicin-induced cardiotoxicity by targeting sestrin 2. Redox Biology. 2022 Jun:52:102310.(中科院1区,Top期刊,发表当年5-Year IF=12.038;独立通讯作者)
(8)Junlian Gu†, Xiaoqing Yan†, Xiaozhen Dai, Yuehui Wang, Qian Lin, Jian Xiao, Shanshan Zhou, Jian Zhang, Kai Wang, Jun Zeng, Ying Xin, Michelle T Barati, Chi Zhang, Yang Bai, Yan Li, Paul N Epstein, Kupper A Wintergerst, Xiaokun Li, Yi Tan, Lu Cai. Metallothionein preserves Akt2 activity and cardiac function via inhibiting TRB3 in diabetic hearts. Diabetes. 2018 Mar;67(3):507-517.(中科院1区,Top期刊,发表当年5-Year IF=8.071;共同第一作者)
(9)Junlian Gu†, Yanli Cheng†, Hao Wu, Lili Kong, Shudong Wang, Zheng Xu, Zhiguo Zhang, Yi Tan, Bradley B Keller, Honglan Zhou, Yuehui Wang, Zhonggao Xu, Lu Cai. Metallothionein is Downstream of Nrf2 and Partially Mediates Sulforaphane Prevention of Diabetic Cardiomyopathy. Diabetes. 2017 Feb;66(2):529-542.(中科院1区,Top期刊,发表当年5-Year IF=8.154;共同第一作者)
(10)Zhifeng Huang†, Yi Tan†, Junlian Gu†, Yang Liu, Lintao Song, Jianlou Niu, Longwei Zhao, Lakshmi Srinivasan, Qian Lin, Jingjing Deng, Yang Li, Daniel J Conklin, Thomas A Neubert, Lu Cai, Xiaokun Li, Moosa Mohammadi. Uncoupling the Mitogenic and Metabolic Functions of FGF1 by Tuning FGF1-FGF Receptor Dimer Stability. Cell Reports. 2017 Aug 15;20(7):1717-1728.(中科院1区,Top期刊,发表当年5-Year IF=8.700;共同第一作者)